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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50434666
Substrate
n/a
Meas. Tech.
ChEMBL_960798 (CHEMBL2387967)
Ki
0.022000±n/a nM
Citation
 Wang, X; Magnuson, S; Pastor, R; Fan, E; Hu, H; Tsui, V; Deng, W; Murray, J; Steffek, M; Wallweber, H; Moffat, J; Drummond, J; Chan, G; Harstad, E; Ebens, AJ Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. Bioorg Med Chem Lett 23:3149-53 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Human
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50434666
Synonyms:
CHEMBL2387471
Type:
Small organic molecule
Emp. Form.:
C26H24F2N8O
Mol. Mass.:
502.5186
SMILES:
Fc1cccc(F)c1-c1cnc2[nH]cc(NC(=O)c3cnn4ccc(NCC5CCNCC5)nc34)c2c1
Structure:
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