Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50190543
Substrate
n/a
Meas. Tech.
ChEMBL_979586 (CHEMBL2424397)
Ki
46000±n/a nM
Citation
 Hampton, SE; Schipani, A; Bosch-Navarrete, C; Recio, E; Kaiser, M; Kahnberg, P; González-Pacanowska, D; Johansson, NG; Gilbert, IH Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorg Med Chem 21:5876-85 (2013) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Human
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50190543
Synonyms:
1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL377582
Type:
Small organic molecule
Emp. Form.:
C28H27N3O4
Mol. Mass.:
469.5317
SMILES:
O[C@H]1C[C@@H](O[C@@H]1CNC(c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: