Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50439339
Substrate
n/a
Meas. Tech.
ChEMBL_979586 (CHEMBL2424397)
Ki
1000000±n/a nM
Citation
 Hampton, SE; Schipani, A; Bosch-Navarrete, C; Recio, E; Kaiser, M; Kahnberg, P; González-Pacanowska, D; Johansson, NG; Gilbert, IH Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorg Med Chem 21:5876-85 (2013) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Human
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50439339
Synonyms:
CHEMBL2420336
Type:
Small organic molecule
Emp. Form.:
C27H25N3O3
Mol. Mass.:
439.5057
SMILES:
O=C(NCCCn1ccc(=O)[nH]c1=O)C(c1ccccc1)(c1ccccc1)c1ccccc1
Structure:
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