Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN3
Ligand
BDBM50446883
Substrate
n/a
Meas. Tech.
ChEMBL_1290489 (CHEMBL3119780)
EC50
400±n/a nM
Citation
 Rabinowitz, MH Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. J Med Chem 56:9369-402 (2014) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Human
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM50446883
Synonyms:
CHEMBL3115283
Type:
Small organic molecule
Emp. Form.:
C24H23Cl2N3O5
Mol. Mass.:
504.363
SMILES:
CC(C)(C)c1ccc(Cn2c(nc(O)c(C(=O)NCC(O)=O)c2=O)-c2c(Cl)cccc2Cl)cc1 |(69.68,-13.82,;68.34,-13.06,;68.33,-11.52,;69.67,-12.27,;67.01,-13.83,;67.02,-15.38,;65.69,-16.15,;64.36,-15.38,;63.03,-16.16,;63.04,-17.7,;61.72,-18.47,;61.72,-20.02,;63.05,-20.78,;63.06,-22.32,;64.39,-20.01,;65.72,-20.77,;65.73,-22.31,;67.06,-20,;68.39,-20.76,;69.72,-19.99,;71.06,-20.75,;69.72,-18.45,;64.38,-18.46,;65.71,-17.68,;60.38,-17.71,;60.39,-16.17,;61.72,-15.4,;59.05,-15.4,;57.72,-16.18,;57.73,-17.72,;59.06,-18.48,;59.07,-20.02,;64.34,-13.85,;65.67,-13.07,)|
Structure:
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