Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50007639
Substrate
n/a
Meas. Tech.
ChEMBL_1339578 (CHEMBL3243058)
IC50
0.500000±n/a nM
Citation
Gonzalez, AZ; Eksterowicz, J; Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chow, D; Duquette, J; Fox, BM; Fu, J; Huang, X; Houze, JB; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; McMinn, DL; Oliner, JD; Osgood, T; Rew, Y; Saiki, AY; Shaffer, P; Wortman, S; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J; Olson, SH; Medina, JC; Sun, D Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem 57:2472-88 (2014) [PubMed] Article
More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Human
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP