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Target
Casein kinase I isoform delta
Ligand
BDBM50025020
Substrate
n/a
Meas. Tech.
ChEMBL_1440400 (CHEMBL3386213)
IC50
40±n/a nM
Citation
 Richter, J; Bischof, J; Zaja, M; Kohlhof, H; Othersen, O; Vitt, D; Alscher, V; Pospiech, I; García-Reyes, B; Berg, S; Leban, J; Knippschild, U Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1d ande with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem 57:7933-46 (2014) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta
Type:
Enzyme
Mol. Mass.:
47342.73
Organism:
Rat
Description:
Q06486
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50025020
Synonyms:
CHEMBL3337854
Type:
Small organic molecule
Emp. Form.:
C20H11F6N5O3S
Mol. Mass.:
515.388
SMILES:
FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F
Structure:
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