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Target
Adenosylhomocysteinase
Ligand
BDBM50050886
Substrate
n/a
Meas. Tech.
ChEMBL_1459288 (CHEMBL3367518)
IC50
17000±n/a nM
Citation
 Nakao, A; Suzuki, H; Ueno, H; Iwasaki, H; Setsuta, T Discovery of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs. Bioorg Med Chem Lett 24:4336-40 (2014) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50050886
Synonyms:
CHEMBL3322538
Type:
Small organic molecule
Emp. Form.:
C31H34Cl2N4O3
Mol. Mass.:
581.533
SMILES:
Clc1ccc(Oc2ccc(Cl)cc2N(CC(=O)NCCN2CCCC2)CC(=O)N2CCc3ccccc3C2)cc1
Structure:
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