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Target
Bcl-2-like protein 1
Ligand
BDBM50067466
Substrate
n/a
Meas. Tech.
ChEMBL_1465156 (CHEMBL3405857)
Ki
520±n/a nM
Citation
 Wan, Y; Wu, S; Xiao, G; Liu, T; Hou, X; Chen, C; Guan, P; Yang, X; Fang, H Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorg Med Chem 23:1994-2003 (2015) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50067466
Synonyms:
CHEMBL3401793
Type:
Small organic molecule
Emp. Form.:
C31H23BrN2O4S3
Mol. Mass.:
663.624
SMILES:
Brc1ccc(C[C@H](N2C(=S)S\C(=C/c3ccc(cc3)-c3ccccc3)C2=O)C(=O)NS(=O)(=O)c2ccccc2)cc1 |r|
Structure:
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