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Target
Serine/threonine-protein kinase PAK 1
Ligand
BDBM50097142
Substrate
n/a
Meas. Tech.
ChEMBL_1499557 (CHEMBL3584415)
Ki
346±n/a nM
Citation
 Crawford, JJ; Lee, W; Aliagas, I; Mathieu, S; Hoeflich, KP; Zhou, W; Wang, W; Rouge, L; Murray, L; La, H; Liu, N; Fan, PW; Cheong, J; Heise, CE; Ramaswamy, S; Mintzer, R; Liu, Y; Chao, Q; Rudolph, J Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors. J Med Chem 58:5121-36 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 1
Synonyms:
2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK
Type:
n/a
Mol. Mass.:
60640.15
Organism:
Homo sapiens (Human)
Description:
Q13153
Residue:
545
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
  
Inhibitor
Name:
BDBM50097142
Synonyms:
CHEMBL3580965
Type:
Small organic molecule
Emp. Form.:
C17H20N8
Mol. Mass.:
336.3943
SMILES:
CNc1ccc(CNc2nccc(Nc3cc([nH]n3)C3CC3)n2)cn1
Structure:
Search PDB for entries with ligand similarity: