Reaction Details Report a problem with these data
Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM50099146
Substrate
n/a
Meas. Tech.
ChEMBL_1459715 (CHEMBL3370433)
Kd
10200±n/a nM
Citation
 Galdeano, C; Gadd, MS; Soares, P; Scaffidi, S; Van Molle, I; Birced, I; Hewitt, S; Dias, DM; Ciulli, A Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem 57:8657-63 (2014) [PubMed]  Article 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Human
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM50099146
Synonyms:
CHEMBL3344077
Type:
Small organic molecule
Emp. Form.:
C22H29N3O4
Mol. Mass.:
399.4834
SMILES:
Cc1ncoc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(C)(C)C)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: