Reaction Details Report a problem with these data
Target
Ornithine aminotransferase, mitochondrial
Ligand
BDBM50199989
Substrate
n/a
Meas. Tech.
ChEMBL_1522254 (CHEMBL3626483)
Ki
4.2±n/a nM
Citation
 Zigmond, E; Ben Ya'acov, A; Lee, H; Lichtenstein, Y; Shalev, Z; Smith, Y; Zolotarov, L; Ziv, E; Kalman, R; Le, HV; Lu, H; Silverman, RB; Ilan, Y Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. ACS Med Chem Lett 6:840-4 (2015) [PubMed]  Article 
Target
Name:
Ornithine aminotransferase, mitochondrial
Synonyms:
OAT | OAT_HUMAN | Ornithine aminotransferase, hepatic form | Ornithine aminotransferase, mitochondrial | Ornithine aminotransferase, renal form | Ornithine delta-aminotransferase | Ornithine--oxo-acid aminotransferase
Type:
PROTEIN
Mol. Mass.:
48537.27
Organism:
Human
Description:
ChEMBL_102740
Residue:
439
Sequence:
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
  
Inhibitor
Name:
BDBM50199989
Synonyms:
(1S,3S)-3-amino-4-(2,2,2-trifluoro-1-trifluoromethylethylidene)cyclopentane | CHEMBL220453
Type:
Small organic molecule
Emp. Form.:
C9H9F6NO2
Mol. Mass.:
277.1637
SMILES:
[#7]-[#6@H]1-[#6]-[#6@H](-[#6]\[#6]-1=[#6](\C(F)(F)F)C(F)(F)F)-[#6](-[#8])=O |r|
Structure:
Search PDB for entries with ligand similarity: