Reaction Details Report a problem with these data
Target
Carbonic anhydrase
Ligand
BDBM10883
Substrate
n/a
Meas. Tech.
ChEMBL_1543853 (CHEMBL3749743)
Ki
8.5±n/a nM
Citation
 Vullo, D; Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorg Med Chem Lett 26:401-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase
Synonyms:
4.2.1.1 | Carbonate dehydratase
Type:
PROTEIN
Mol. Mass.:
28438.71
Organism:
Sulfurihydrogenibium sp. (strain YO3AOP1)
Description:
ChEMBL_116696
Residue:
246
Sequence:
MRKILISAVLVLSSISISFAEHEWSYEGEKGPEHWAQLKPEFFWCKLKNQSPINIDKKYKVKANLPKLNLYYKTAKESEVVNNGHTIQINIKEDNTLNYLGEKYQLKQFHFHTPSEHTIEKKSYPLEIHFVHKTEDGKILVVGVMAKLGKTNKELDKILNVAPAEEGEKILDKNLNLNNLIPKDKRYMTYSGSLTTPPCTEGVRWIVLKKPISISKQQLEKLKSVMVNPNNRPVQEINSRWIIEGF
  
Inhibitor
Name:
BDBM10883
Synonyms:
4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 | Dichlorophenamide | Dichlorophenamide (DCP) | Dichlorophenamide, DCP | Sulfonamide, 4 | US10172837, Dichlorphenamide | sulfonamide 4
Type:
Small organic molecule
Emp. Form.:
C6H6Cl2N2O4S2
Mol. Mass.:
305.159
SMILES:
NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
Structure:
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