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Target
Serine/threonine-protein kinase PAK 1
Ligand
BDBM50148931
Substrate
n/a
Meas. Tech.
ChEMBL_1557609 (CHEMBL3772526)
IC50
222±n/a nM
Citation
 Ndubaku, CO; Crawford, JJ; Drobnick, J; Aliagas, I; Campbell, D; Dong, P; Dornan, LM; Duron, S; Epler, J; Gazzard, L; Heise, CE; Hoeflich, KP; Jakubiak, D; La, H; Lee, W; Lin, B; Lyssikatos, JP; Maksimoska, J; Marmorstein, R; Murray, LJ; O'Brien, T; Oh, A; Ramaswamy, S; Wang, W; Zhao, X; Zhong, Y; Blackwood, E; Rudolph, J Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett 6:1241-6 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 1
Synonyms:
2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK
Type:
n/a
Mol. Mass.:
60640.15
Organism:
Homo sapiens (Human)
Description:
Q13153
Residue:
545
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
  
Inhibitor
Name:
BDBM50148931
Synonyms:
CHEMBL3770186
Type:
Small organic molecule
Emp. Form.:
C28H32ClN7O
Mol. Mass.:
518.053
SMILES:
CCn1c2nc(NCCC3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncc(C)n2)c1=O
Structure:
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