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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50152153
Substrate
n/a
Meas. Tech.
ChEMBL_1563594 (CHEMBL3783530)
IC50
1700±n/a nM
Citation
 Banoglu, E; Çelikoglu, E; Völker, S; Olgaç, A; Gerstmeier, J; Garscha, U; Çaliskan, B; Schubert, US; Carotti, A; Macchiarulo, A; Werz, O 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). Eur J Med Chem 113:1-10 (2016) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50152153
Synonyms:
CHEMBL3781057
Type:
Small organic molecule
Emp. Form.:
C24H18ClNO4
Mol. Mass.:
419.857
SMILES:
Cc1ccccc1COc1ccc(cc1)-c1onc(C(O)=O)c1-c1ccc(Cl)cc1
Structure:
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