Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 3
Ligand
BDBM50152776
Substrate
n/a
Meas. Tech.
ChEMBL_1565338 (CHEMBL3782732)
IC50
64±n/a nM
Citation
 Siebeneicher, H; Bauser, M; Buchmann, B; Heisler, I; Müller, T; Neuhaus, R; Rehwinkel, H; Telser, J; Zorn, L Identification of novel GLUT inhibitors. Bioorg Med Chem Lett 26:1732-7 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 3
Synonyms:
GLUT-3 | GLUT3 | GTR3_HUMAN | Glucose transporter type 3, brain | SLC2A3 | Solute carrier family 2, facilitated glucose transporter member 3
Type:
PROTEIN
Mol. Mass.:
53925.15
Organism:
Human
Description:
ChEMBL_101113
Residue:
496
Sequence:
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
  
Inhibitor
Name:
BDBM50152776
Synonyms:
CHEMBL3780785
Type:
Small organic molecule
Emp. Form.:
C22H22N6O
Mol. Mass.:
386.4497
SMILES:
COc1ccccc1N1CCN(CC1)c1ncnc2n(cnc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: