Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50171077
Substrate
n/a
Meas. Tech.
ChEMBL_1576856 (CHEMBL3806500)
IC50
>25000±n/a nM
Citation
 McDaniel, TJ; Lansdell, TA; Dissanayake, AA; Azevedo, LM; Claes, J; Odom, AL; Tepe, JJ Substituted quinolines as noncovalent proteasome inhibitors. Bioorg Med Chem 24:2441-50 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50171077
Synonyms:
CHEMBL3805957
Type:
Small organic molecule
Emp. Form.:
C15H20N2
Mol. Mass.:
228.3327
SMILES:
CN(C)c1ccc2ncc(cc2c1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: