Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50174153
Substrate
n/a
Meas. Tech.
ChEMBL_1581410 (CHEMBL3812017)
IC50
0.300000±n/a nM
Citation
Cee, VJ; Chavez, F; Herberich, B; Lanman, BA; Pettus, LH; Reed, AB; Wu, B; Wurz, RP; Andrews, KL; Chen, J; Hickman, D; Laszlo, J; Lee, MR; Guerrero, N; Mattson, BK; Nguyen, Y; Mohr, C; Rex, K; Sastri, CE; Wang, P; Wu, Q; Wu, T; Xu, Y; Zhou, Y; Winston, JT; Lipford, JR; Tasker, AS; Wang, HL Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. ACS Med Chem Lett 7:408-12 (2016) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK