Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50205565
Substrate
n/a
Meas. Tech.
ChEMBL_1628397 (CHEMBL3870982)
Ki
>10000±n/a nM
Citation
 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII. Bioorg Med Chem Lett 27:86-89 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50205565
Synonyms:
CHEMBL3890627
Type:
Small organic molecule
Emp. Form.:
C24H26N4O3
Mol. Mass.:
418.4882
SMILES:
CC1(C)CC(=O)C2=C(C1)OC1=C(C2c2ccc(cc2)-c2nnn[nH]2)C(=O)CC(C)(C)C1 |c:6,11|
Structure:
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