Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50207069
Substrate
n/a
Meas. Tech.
ChEMBL_1629518 (CHEMBL3872144)
EC50
>10000±n/a nM
Citation
 Adams, GL; Velazquez, F; Jayne, C; Shah, U; Miao, S; Ashley, ER; Madeira, M; Akiyama, TE; Di Salvo, J; Suzuki, T; Wang, N; Truong, Q; Gilbert, E; Zhou, D; Verras, A; Kirkland, M; Pachanski, M; Powles, M; Yin, W; Ujjainwalla, F; Venkatraman, S; Edmondson, SD Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with ACS Med Chem Lett 8:96-101 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50207069
Synonyms:
CHEMBL3959068
Type:
Small organic molecule
Emp. Form.:
C24H24F2O5
Mol. Mass.:
430.4412
SMILES:
[H][C@]1(C[C@@]1([H])[C@@]1([H])CCc2cc(ccc2O1)-c1cc(O[C@H]2C[C@@H](C2)OC)cc(F)c1F)C(O)=O |r,wU:5.6,1.0,20.22,wD:3.4,22.27,(25.35,-14.1,;25.76,-15.6,;25.75,-17.14,;24.43,-16.36,;24.41,-17.9,;23.08,-15.59,;22.96,-17.12,;23.09,-14.03,;21.74,-13.25,;20.4,-14.03,;19.07,-13.27,;17.74,-14.04,;17.73,-15.59,;19.06,-16.36,;20.39,-15.59,;21.74,-16.36,;16.4,-13.27,;15.07,-14.04,;13.74,-13.27,;12.4,-14.05,;11.07,-13.29,;9.59,-13.69,;9.19,-12.21,;10.67,-11.8,;7.86,-11.45,;7.86,-9.92,;13.73,-11.73,;15.07,-10.95,;15.07,-9.43,;16.41,-11.72,;17.74,-10.95,;27.1,-16.37,;27.09,-17.91,;28.43,-15.6,)|
Structure:
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