Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM50237202
Substrate
n/a
Meas. Tech.
ChEMBL_1660723 (CHEMBL4010335)
IC50
1.4±n/a nM
Citation
Gopalsamy, A; Narayanan, A; Liu, S; Parikh, MD; Kyne, RE; Fadeyi, O; Tones, MA; Cherry, JJ; Nabhan, JF; LaRosa, G; Petersen, DN; Menard, C; Foley, TL; Noell, S; Ren, Y; Loria, PM; Maglich-Goodwin, J; Rong, H; Jones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem 60:3094-3108 (2017) [PubMed] Article
More Info.:
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Human
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS