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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50110999
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_4453
Citation
 Riendeau, D; Percival, MD; Brideau, C; Charleson, S; Dubé, D; Ethier, D; Falgueyret, JP; Friesen, RW; Gordon, R; Greig, G; Guay, J; Mancini, J; Ouellet, M; Wong, E; Xu, L; Boyce, S; Visco, D; Girard, Y; Prasit, P; Zamboni, R; Rodger, IW; Gresser, M; Ford-Hutchinson, AW; Young, RN; Chan, CC Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther 296:558-66 (2001) [PubMed] 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Homo sapiens (Human)
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50110999
Synonyms:
4-(4-Cyclohexyl-2-methyl-oxazol-5-yl)-2-fluoro-benzenesulfonamide | CHEMBL34913 | JTE-522 | Tilmacoxib
Type:
Small organic molecule
Emp. Form.:
C16H19FN2O3S
Mol. Mass.:
338.397
SMILES:
Cc1nc(C2CCCCC2)c(o1)-c1ccc(c(F)c1)S(N)(=O)=O
Structure:
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