Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249551
Substrate
n/a
Meas. Tech.
TR-FRET Assay for Retinol-induced RBP4-TTR Interaction
pH
7.5±n/a
IC50
5.91±n/a nM
Comments
extracted
Citation
Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent US10072016 Publication Date 9/11/2018
More Info.:
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Human
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
Inhibitor
Name:
BDBM249551
Synonyms:
US10072016, Compound 149 | US10407433, Compound 149 | US10913746, Compound 149 | US11649240, Compound 149 | US9434727, 149 | US9777010, Compound 149
Type:
Small organic molecule
Emp. Form.:
C21H24ClFN4O2
Mol. Mass.:
418.892
SMILES:
Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C2COC2)c1Cl