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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90225
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90225
Synonyms:
MLS000390260 | N-[2-chloranyl-5-(trifluoromethyl)phenyl]-2-(1-oxidanidylpyridin-1-ium-2-yl)sulfanyl-2-phenyl-ethanamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2-phenylacetamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[(1-oxido-2-pyridin-1-iumyl)thio]-2-phenylacetamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[(1-oxidopyridin-1-ium-2-yl)thio]-2-phenyl-acetamide | SMR000259524 | cid_4170622
Type:
Small organic molecule
Emp. Form.:
C20H14ClF3N2O2S
Mol. Mass.:
438.851
SMILES:
[O-][n+]1ccccc1SC(C(=O)Nc1cc(ccc1Cl)C(F)(F)F)c1ccccc1
Structure:
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