Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM92507
Substrate
BDBM92519
Meas. Tech.
Tautomerase Enzyme Assay
pH
6.5±0
Ki
2.47e+3±n/a nM
IC50
7.08e+3±n/a nM
Citation
Ouertatani-Sakouhi, H; El-Turk, F; Fauvet, B; Cho, MK; Pinar Karpinar, D; Le Roy, D; Dewor, M; Roger, T; Bernhagen, J; Calandra, T; Zweckstetter, M; Lashuel, HA Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. J Biol Chem 285:26581-98 (2010) [PubMed] Article
More Info.:
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Inhibitor
Name:
BDBM92507
Synonyms:
DFP 00129, 2
Type:
Small organic molecule
Emp. Form.:
C12H8ClN3O3S2
Mol. Mass.:
341.793
SMILES:
[O-][N+](=O)c1cc(cs1)C(=O)NC(=S)Nc1ccccc1Cl