Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM93204
Substrate
n/a
Meas. Tech.
Fluorometric High-Throughput Assay
pH
5.5±0
Ki
2.0±0.3 nM
Citation
 Wood, WJ; Huang, L; Ellman, JA Synthesis of a diverse library of mechanism-based cysteine protease inhibitors. J Comb Chem 5:869-80 (2003) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM93204
Synonyms:
Mercaptomethyl ketone Inhibitor, 53
Type:
Small molecule
Emp. Form.:
C26H33N3O7S
Mol. Mass.:
531.621
SMILES:
NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(=O)CSCC(O)=O |r|
Structure:
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