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Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94721
Substrate
n/a
EC50
11600±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Human
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94721
Synonyms:
3-[2-(pentylamino)ethanoylamino]-N-[3-(trifluoromethyl)phenyl]benzamide | 3-[[1-oxo-2-(pentylamino)ethyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide | 3-[[2-(amylamino)acetyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide | 3-[[2-(pentylamino)acetyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide | MLS000374810 | SMR000254164 | cid_3278258
Type:
Small organic molecule
Emp. Form.:
C21H24F3N3O2
Mol. Mass.:
407.4294
SMILES:
CCCCCNCC(=O)Nc1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
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