Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94726
Substrate
n/a
EC50
>80000±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Human
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94726
Synonyms:
1-[1-(2,5-dimethylphenyl)-3-phenyl-1H-pyrazol-4-yl]-N-{[1-(2-methoxyethyl)pyrrolidin-3-yl]methyl}methanamine | MLS000733847 | N-[[1-(2,5-dimethylphenyl)-3-phenyl-4-pyrazolyl]methyl]-1-[1-(2-methoxyethyl)-3-pyrrolidinyl]methanamine | N-[[1-(2,5-dimethylphenyl)-3-phenyl-pyrazol-4-yl]methyl]-1-[1-(2-methoxyethyl)pyrrolidin-3-yl]methanamine | N-[[1-(2,5-dimethylphenyl)-3-phenylpyrazol-4-yl]methyl]-1-[1-(2-methoxyethyl)pyrrolidin-3-yl]methanamine | SMR000316780 | [1-(2,5-dimethylphenyl)-3-phenyl-pyrazol-4-yl]methyl-[[1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]amine | cid_16191926
Type:
Small organic molecule
Emp. Form.:
C26H34N4O
Mol. Mass.:
418.5744
SMILES:
COCCN1CCC(CNCc2cn(nc2-c2ccccc2)-c2cc(C)ccc2C)C1
Structure:
Search PDB for entries with ligand similarity: