Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94741
Substrate
n/a
EC50
8570±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Human
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94741
Synonyms:
1-(3-chloranyl-4-fluoranyl-phenyl)-3-[[1-[(3-methylphenyl)methyl]piperidin-4-yl]methyl]urea | 1-(3-chloro-4-fluoro-phenyl)-3-[[1-(3-methylbenzyl)-4-piperidyl]methyl]urea | 1-(3-chloro-4-fluorophenyl)-3-[[1-[(3-methylphenyl)methyl]-4-piperidinyl]methyl]urea | 1-(3-chloro-4-fluorophenyl)-3-[[1-[(3-methylphenyl)methyl]piperidin-4-yl]methyl]urea | MLS001200217 | N-(3-chloro-4-fluorophenyl)-N'-{[1-(3-methylbenzyl)piperidin-4-yl]methyl}urea | SMR000563489 | cid_23609268
Type:
Small organic molecule
Emp. Form.:
C21H25ClFN3O
Mol. Mass.:
389.894
SMILES:
Cc1cccc(CN2CCC(CNC(=O)Nc3ccc(F)c(Cl)c3)CC2)c1
Structure:
Search PDB for entries with ligand similarity: