Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM100369
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5.0±0.0 nM
Citation
 Hammock, BD; Jones, PD; Morisseau, C; Huang, H; Tsai, H; Gless, Jr., R Conformationally restricted urea inhibitors of soluble epoxide hydrolase US Patent  US8501783 Publication Date 8/6/2013 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM100369
Synonyms:
US8501783, 1156
Type:
Small organic molecule
Emp. Form.:
C19H31N3O2
Mol. Mass.:
333.4683
SMILES:
CC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 |THB:20:12:15:19.17.18,20:18:15:13.12.21,17:16:13:20.19.18,17:18:13:16.15.21|
Structure:
Search PDB for entries with ligand similarity: