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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102509
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
10±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102509
Synonyms:
US8536175, 22
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O3
Mol. Mass.:
501.365
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2nccnc12 |(7.42,4,;8.19,2.67,;7.42,1.33,;8.19,,;7.42,-1.33,;8.19,-2.67,;9.73,-2.67,;5.88,-1.33,;5.11,-2.67,;5.11,,;5.88,1.33,;5.11,2.67,;3.57,,;2.8,1.33,;1.26,1.33,;.49,,;-1.05,,;-1.82,1.33,;-1.82,-1.33,;-3.36,-1.33,;-4.26,-.09,;-5.73,-.56,;-5.73,-2.1,;-7.06,-2.87,;-8.4,-2.1,;-8.4,-.56,;-9.73,-2.87,;-4.26,-2.58,;1.26,-1.33,;.49,-2.67,;1.26,-4,;2.8,-4,;3.57,-2.67,;2.8,-1.33,)|
Structure:
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