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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102510
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
530±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102510
Synonyms:
US8536175, 24
Type:
Small organic molecule
Emp. Form.:
C22H16Cl2N4O4
Mol. Mass.:
471.293
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c2nccnc12 |(6.55,4,;7.32,2.67,;6.55,1.33,;7.31,,;6.55,-1.33,;7.32,-2.67,;8.86,-2.67,;5.01,-1.33,;4.23,-2.67,;4.23,,;5.01,1.33,;4.23,2.67,;2.69,,;1.93,1.33,;.38,1.33,;-.38,,;-1.92,,;-2.69,1.33,;-2.69,-1.33,;-4.23,-1.33,;-5,,;-6.54,,;-7.31,-1.33,;-8.85,-1.33,;-6.54,-2.67,;-5,-2.67,;.38,-1.33,;-.38,-2.67,;.38,-4,;1.93,-4,;2.69,-2.67,;1.93,-1.33,)|
Structure:
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