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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102512
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
22±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102512
Synonyms:
US8536175, 31
Type:
Small organic molecule
Emp. Form.:
C28H28Cl2N6O3
Mol. Mass.:
567.466
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(10.38,-2.67,;8.84,-2.67,;8.07,-1.33,;8.84,,;8.07,1.33,;8.84,2.67,;8.07,4,;6.53,1.33,;5.76,2.67,;5.76,,;6.53,-1.33,;5.76,-2.67,;4.22,,;3.45,1.33,;1.91,1.33,;1.14,,;-.4,,;-1.17,1.33,;-1.17,-1.33,;-2.71,-1.33,;-3.48,,;-5.02,,;-5.79,-1.33,;-7.33,-1.33,;-8.1,,;-7.33,1.33,;-8.08,2.65,;-9.61,2.65,;-10.38,3.98,;-10.36,1.33,;-9.64,,;-5.02,-2.67,;-3.48,-2.67,;1.91,-1.33,;1.14,-2.67,;1.91,-4,;3.45,-4,;4.22,-2.67,;3.45,-1.33,)|
Structure:
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