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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102514
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
270±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102514
Synonyms:
US8536175, 38
Type:
Small organic molecule
Emp. Form.:
C27H28Cl2N6O3
Mol. Mass.:
555.456
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(nc2)N(C)CCN(C)C)c2nccnc12 |(11.17,2.67,;9.63,2.67,;8.86,1.33,;9.63,,;8.86,-1.33,;9.63,-2.67,;11.17,-2.67,;7.31,-1.33,;6.55,-2.67,;6.55,,;7.31,1.33,;6.55,2.67,;5.01,,;4.24,1.33,;2.7,1.33,;1.92,,;.39,,;-.39,1.33,;-.39,-1.33,;-1.92,-1.33,;-2.7,,;-4.24,,;-5.01,-1.33,;-4.24,-2.67,;-2.7,-2.67,;-6.55,-1.33,;-7.32,-2.67,;-7.32,,;-8.86,,;-9.63,-1.33,;-8.86,-2.67,;-11.17,-1.33,;2.7,-1.33,;1.92,-2.67,;2.7,-4,;4.24,-4,;5.01,-2.67,;4.24,-1.33,)|
Structure:
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