Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM102521
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
605±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102521
Synonyms:
US8536175, 82
Type:
Small organic molecule
Emp. Form.:
C29H30Cl2N6O3
Mol. Mass.:
581.493
SMILES:
CCN1CCN(Cc2cnc3c(ccc(C(=O)Nc4cccnc4)c3n2)-c2c(Cl)c(OC)cc(OC)c2Cl)CC1 |(-8.08,-5.33,;-7.31,-4,;-5.78,-4,;-5,-2.67,;-3.47,-2.67,;-2.69,-4,;-1.15,-4,;-.38,-2.67,;1.15,-2.67,;1.93,-1.33,;1.15,,;1.93,1.33,;1.15,2.67,;-.38,2.67,;-1.15,1.33,;-2.69,1.33,;-3.47,2.67,;-3.47,,;-5,,;-5.78,1.33,;-7.31,1.33,;-8.08,,;-7.31,-1.33,;-5.78,-1.33,;-.38,,;-1.15,-1.33,;3.47,1.33,;4.23,,;3.47,-1.33,;5.78,,;6.55,-1.33,;8.09,-1.33,;6.55,1.33,;5.78,2.67,;6.55,4,;5.78,5.33,;4.23,2.67,;3.47,4,;-3.47,-5.33,;-5,-5.33,)|
Structure:
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