Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM102522
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
945±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102522
Synonyms:
US8536175, 83
Type:
Small organic molecule
Emp. Form.:
C29H30Cl2N6O3
Mol. Mass.:
581.493
SMILES:
CCN1CCN(Cc2cnc3c(ccc(-c4c(Cl)c(OC)cc(OC)c4Cl)c3n2)C(=O)Nc2cccnc2)CC1 |(8.47,-5.33,;7.7,-4,;6.16,-4,;5.39,-5.33,;3.85,-5.33,;3.08,-4,;1.54,-4,;.77,-2.67,;-.77,-2.67,;-1.54,-1.33,;-.77,,;-1.54,1.33,;-.77,2.67,;.77,2.67,;1.54,1.33,;3.08,1.33,;3.85,,;3.08,-1.33,;5.39,,;6.16,-1.33,;7.7,-1.33,;6.16,1.33,;5.39,2.67,;6.16,4,;5.39,5.33,;3.85,2.67,;3.08,4,;.77,,;1.54,-1.33,;-3.08,1.33,;-3.85,2.67,;-3.85,,;-5.39,,;-6.16,1.33,;-7.7,1.33,;-8.47,,;-7.7,-1.33,;-6.16,-1.33,;3.85,-2.67,;5.39,-2.67,)|
Structure:
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