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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102525
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
485±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102525
Synonyms:
US8536175, 91
Type:
Small organic molecule
Emp. Form.:
C22H16F2N4O3
Mol. Mass.:
422.3842
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccccn2)c2nccnc12 |(8.09,-2.67,;6.55,-2.67,;5.78,-1.33,;6.55,,;5.78,1.33,;6.55,2.67,;5.78,4,;4.23,1.33,;3.47,2.67,;3.47,,;4.23,-1.33,;3.47,-2.67,;1.93,,;1.15,1.33,;-.38,1.33,;-1.15,,;-2.69,,;-3.47,1.33,;-3.47,-1.33,;-5,-1.33,;-5.78,,;-7.31,,;-8.08,-1.33,;-7.31,-2.67,;-5.78,-2.67,;-.38,-1.33,;-1.15,-2.67,;-.38,-4,;1.15,-4,;1.93,-2.67,;1.15,-1.33,)|
Structure:
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