Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM102526
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
7±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102526
Synonyms:
US8536175, 93
Type:
Small organic molecule
Emp. Form.:
C25H24F2N6O3
Mol. Mass.:
494.4933
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12 |(10.25,-2.72,;8.71,-2.72,;7.94,-1.38,;8.71,-.05,;7.94,1.28,;8.71,2.62,;7.94,3.95,;6.4,1.28,;5.63,2.62,;5.63,-.05,;6.4,-1.38,;5.63,-2.72,;4.09,-.05,;3.32,1.28,;1.78,1.28,;1.01,-.05,;-.53,-.05,;-1.3,1.28,;-1.3,-1.38,;-2.84,-1.38,;-3.74,-.14,;-5.21,-.61,;-5.21,-2.15,;-6.54,-2.92,;-7.88,-2.15,;-8.35,-.69,;-9.89,-.69,;-10.37,-2.15,;-9.12,-3.06,;-3.74,-2.63,;1.78,-1.38,;1.01,-2.72,;1.78,-4.05,;3.32,-4.05,;4.09,-2.72,;3.32,-1.38,)|
Structure:
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