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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102529
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1050±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102529
Synonyms:
US8536175, 98
Type:
Small organic molecule
Emp. Form.:
C30H33ClN6O2
Mol. Mass.:
545.075
SMILES:
CCN1CCN(Cc2ccc(NC(=O)c3ccc(-c4c(C)c(OC)cc(C)c4Cl)c4nccnc34)nc2)CC1 |(-8.85,4.67,;-9.62,3.33,;-8.85,2,;-7.31,2,;-6.54,.67,;-7.31,-.67,;-6.54,-2,;-5,-2,;-4.23,-.67,;-2.69,-.67,;-1.92,-2,;-.38,-2,;.39,-.67,;-.38,.67,;1.93,-.67,;2.7,.67,;4.24,.67,;5.01,-.67,;6.55,-.67,;7.32,.67,;6.55,2,;8.86,.67,;9.63,2,;11.17,2,;9.63,-.67,;8.86,-2,;9.63,-3.33,;7.32,-2,;6.55,-3.33,;4.24,-2,;5.01,-3.33,;4.24,-4.67,;2.7,-4.67,;1.93,-3.33,;2.7,-2,;-2.69,-3.33,;-4.23,-3.33,;-8.85,-.67,;-9.62,.67,)|
Structure:
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