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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102537
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102537
Synonyms:
US8536175, 136
Type:
Small organic molecule
Emp. Form.:
C26H24F2N6O4
Mol. Mass.:
522.5034
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN(C)CC(N)=O)cn2)c2nccnc12 |(11.15,2.66,;9.61,2.66,;8.84,1.32,;9.61,-.01,;8.84,-1.34,;9.61,-2.68,;11.15,-2.68,;7.3,-1.34,;6.53,-2.68,;6.53,-.01,;7.3,1.32,;6.53,2.66,;4.99,-.01,;4.22,1.32,;2.68,1.32,;1.91,-.01,;.37,-.01,;-.4,1.32,;-.4,-1.34,;-1.94,-1.34,;-2.71,-.01,;-4.25,-.01,;-5.02,-1.34,;-6.56,-1.34,;-7.33,-.01,;-6.56,1.32,;-8.87,-.01,;-9.64,1.32,;-8.87,2.66,;-11.18,1.32,;-4.25,-2.68,;-2.71,-2.68,;2.68,-1.34,;1.91,-2.68,;2.68,-4.01,;4.22,-4.01,;4.99,-2.68,;4.22,-1.34,)|
Structure:
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