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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102538
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
265±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102538
Synonyms:
US8536175, 139
Type:
Small organic molecule
Emp. Form.:
C25H25F2N5O3
Mol. Mass.:
481.4945
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccn(CCN(C)C)c2)c2nccnc12 |(9.72,-2.68,;8.18,-2.68,;7.41,-1.34,;8.18,-.01,;7.41,1.32,;8.18,2.66,;7.41,3.99,;5.87,1.32,;5.1,2.66,;5.1,-.01,;5.87,-1.34,;5.1,-2.68,;3.56,-.01,;2.79,1.32,;1.25,1.32,;.48,-.01,;-1.06,-.01,;-1.83,1.32,;-1.83,-1.34,;-3.37,-1.34,;-4.28,-.1,;-5.74,-.57,;-5.74,-2.11,;-7.08,-2.88,;-8.41,-2.11,;-8.41,-.57,;-7.08,.2,;-9.74,.2,;-4.28,-2.59,;1.25,-1.34,;.48,-2.68,;1.25,-4.01,;2.79,-4.01,;3.56,-2.68,;2.79,-1.34,)|
Structure:
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