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Target
Egl nine homolog 1
Ligand
BDBM107718
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
4e+2±n/a nM
Citation
 Kawamoto, RM; Wu, S; Warshakoon, NC; Evdokimov, AG; Greis, KD; Boyer, AS Prolyl hydroxylase inhibitors and methods of use US Patent  US8598210 Publication Date 12/3/2013 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107718
Synonyms:
US8598210, Table XV, 24 | US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]- pyridine-2-carbonyl}-amino)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C15H12N6O4
Mol. Mass.:
340.2936
SMILES:
OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1
Structure:
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