Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM110188
Substrate
n/a
Meas. Tech.
Cathepsin B Inhibition Assay
pH
5.5±n/a
Temperature
310.15±n/a K
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
 Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem 51:24-30 (2013) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM110188
Synonyms:
1-(2,4-Dihydroxyphenyl)-3-(pyridin-2-yl)propenone (8)
Type:
Small organic molecule
Emp. Form.:
C14H11NO3
Mol. Mass.:
241.242
SMILES:
Oc1ccc(C(=O)\C=C\c2ccccn2)c(O)c1
Structure:
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