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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114657
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
10247±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114657
Synonyms:
(5E)-3-benzyl-5-[(2E)-2-(3-methyl-1,3-thiazolidin-2-ylidene)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-3-benzyl-5-[(2E)-2-(3-methylthiazolidin-2-ylidene)ethylidene]-2-thioxo-thiazolidin-4-one | (5E)-5-[(2E)-2-(3-methyl-1,3-thiazolidin-2-ylidene)ethylidene]-3-(phenylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-5-[(2E)-2-(3-methyl-2-thiazolidinylidene)ethylidene]-3-(phenylmethyl)-2-sulfanylidene-4-thiazolidinone | 3-Benzyl-5-[2-(3-methyl-thiazolidin-2-ylidene)-ethylidene]-2-thioxo-thiazolidin-4-one | MLS000551839 | SMR000175780 | cid_5759278
Type:
Small organic molecule
Emp. Form.:
C16H16N2OS3
Mol. Mass.:
348.506
SMILES:
CN1CCS\C1=C\C=C1\SC(=S)N(Cc2ccccc2)C1=O
Structure:
Search PDB for entries with ligand similarity: