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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM51231
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
8920±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM51231
Synonyms:
2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1-ethylbenzimidazole-5-carboxylic acid | 2-[(5-azanyl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1-ethyl-benzimidazole-5-carboxylic acid | 2-[[(5-amino-1H-1,2,4-triazol-3-yl)thio]methyl]-1-ethyl-5-benzimidazolecarboxylic acid | 2-[[(5-amino-1H-1,2,4-triazol-3-yl)thio]methyl]-1-ethyl-benzimidazole-5-carboxylic acid | MLS000774165 | SMR000364979 | cid_2123444
Type:
Small organic molecule
Emp. Form.:
C13H14N6O2S
Mol. Mass.:
318.354
SMILES:
CCn1c(CSc2nnc(N)[nH]2)nc2cc(ccc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: