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Target
Insulin-like growth factor 1 receptor
Ligand
BDBM122863
Substrate
n/a
Meas. Tech.
DELFIA assay
pH
7.4±n/a
IC50
1±n/a nM
Comments
extracted
Citation
 Treu, M Aminopyrazoloquinazolines US Patent  US8735386 Publication Date 5/27/2014 
Target
Name:
Insulin-like growth factor 1 receptor
Synonyms:
CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR)
Type:
Protein
Mol. Mass.:
154776.79
Organism:
Homo sapiens (Human)
Description:
P08069
Residue:
1367
Sequence:
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
  
Inhibitor
Name:
BDBM122863
Synonyms:
US8735386, III-25
Type:
Small organic molecule
Emp. Form.:
C32H34ClN7O2
Mol. Mass.:
584.111
SMILES:
COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CC(C1)N1CCCC1 |(1.48,-3.2,;.15,-2.43,;.15,-.89,;-1.18,-.12,;-1.18,1.42,;.15,2.19,;1.48,1.42,;1.48,-.12,;2.82,-.89,;4.15,-.12,;4.15,1.42,;5.49,2.19,;6.82,1.42,;8.15,2.19,;9.49,1.42,;9.49,-.12,;10.63,-1.15,;10,-2.56,;10.77,-3.89,;8.47,-2.4,;8.15,-.89,;6.82,-.12,;5.49,-.89,;7.38,-3.49,;5.9,-3.09,;4.81,-4.18,;5.21,-5.66,;6.69,-6.06,;7.78,-4.97,;9.27,-5.37,;-2.52,2.19,;-2.52,3.73,;-3.85,1.42,;-5.18,2.19,;-5.58,3.68,;-7.07,3.28,;-6.67,1.79,;-8.4,4.05,;-8.4,5.59,;-9.87,6.06,;-10.77,4.82,;-9.87,3.57,)|
Structure:
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