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Target
Orexin receptor type 2
Ligand
BDBM123336
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay I
pH
7.5±n/a
Temperature
277.15±n/a K
Kd
153±n/a nM
Comments
extracted
Citation
 Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Chebrolu, M; Cotesta, S; Hintermann, S; Meyer, A; Pandit, C Disubstituted heteroaryl-fused pyridines US Patent  US8742106 Publication Date 6/3/2014 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM123336
Synonyms:
US8742106, 1.24
Type:
Small organic molecule
Emp. Form.:
C25H23F3N4O2
Mol. Mass.:
468.4709
SMILES:
C[C@H](NC(=O)COc1cc(c2c(nn(C)c2n1)-c1cccc(C)c1)C(F)(F)F)c1ccccc1 |r|
Structure:
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