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Target
Fibroblast growth factor receptor 3
Ligand
BDBM130076
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
Temperature
298.15±n/a K
IC50
10±n/a nM
Comments
extracted
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8815901 Publication Date 8/26/2014 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM130076
Synonyms:
US8815901, 124
Type:
Small organic molecule
Emp. Form.:
C27H26F2N6O3
Mol. Mass.:
520.5305
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCNCC3)cn2)c2nccnc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.33,;8.85,,;8.08,1.33,;8.85,2.67,;8.08,4,;6.54,1.33,;5.78,2.67,;5.78,,;6.54,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-7.31,-1.33,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,1.33,;-9.63,,;-5,-2.67,;-3.47,-2.67,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)|
Structure:
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