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Target
Fibroblast growth factor receptor 3
Ligand
BDBM130078
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
Temperature
298.15±n/a K
IC50
11±n/a nM
Comments
extracted
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8815901 Publication Date 8/26/2014 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM130078
Synonyms:
US8815901, 135
Type:
Small organic molecule
Emp. Form.:
C25H24F2N6O4
Mol. Mass.:
510.4927
SMILES:
COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.86,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.24,,;3.47,1.33,;1.93,1.33,;1.16,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.6,-.09,;-5.06,-.56,;-5.06,-2.1,;-6.4,-2.87,;-7.73,-2.1,;-7.73,-.56,;-9.06,.21,;-10.4,-.56,;-10.4,-2.1,;-9.06,-2.87,;-3.6,-2.58,;1.93,-1.33,;1.16,-2.67,;1.93,-4,;3.47,-4,;4.24,-2.67,;3.47,-1.33,)|
Structure:
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