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Target
Fibroblast growth factor receptor 3
Ligand
BDBM130081
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
Temperature
298.15±n/a K
IC50
12±n/a nM
Comments
extracted
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8815901 Publication Date 8/26/2014 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM130081
Synonyms:
US8815901, 155
Type:
Small organic molecule
Emp. Form.:
C25H23ClFN7O4
Mol. Mass.:
539.946
SMILES:
COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-9.78,-2.15,;-11.12,-2.92,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)|
Structure:
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