Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM152733
Substrate
n/a
Meas. Tech.
Steady State Kinetics
pH
7.2±n/a
Ki
2e+2±n/a nM
Comments
extracted
Citation
 Hazra, S; Kurz, SG; Wolff, K; Nguyen, L; Bonomo, RA; Blanchard, JS Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the ß-Lactamase from Mycobacterium tuberculosis. Biochemistry 54:5657-64 (2015) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
BLAC_MYCTO | Class A beta-lactamase BlaC (BlaC) | blaA | blaC
Type:
Protein
Mol. Mass.:
32565.98
Organism:
Mycobacterium tuberculosis H37Rv
Description:
n/a
Residue:
307
Sequence:
MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAATCVAGVLA
  
Inhibitor
Name:
BDBM152733
Synonyms:
Penem 2
Type:
Small organic molecule
Emp. Form.:
C13H10N3O3S2
Mol. Mass.:
320.367
SMILES:
[O-]C(=O)C1=CSC2N1C(=O)\C2=C\c1cc2CCSCn2n1 |t:3|
Structure:
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